triterpenes and steroids from euphorbia denticulate lam. with anti-herpes symplex virus activity
نویسندگان
چکیده
in this research, dried acetone:chloroform extract of aerial parts of e. denticulata as one of the endemic plants to iran, afforded a number of triterpenes and steroids including: betulin, 24-methylene-cycloart-3-ol, cycloart-23z-ene-3β,25-diol, cycloart-23z-ene-3β,25-diol, ergosta-8,24-dien-3-ol (obtusifoliol) and beta-sitosterol which were reported for the first time from this plant. the structure of these compounds was elucidated by nmr and mass spectroscopic methods. the mts assay was used to determine the toxicity and antiviral activity of betulin and (3β,23e)-cycloarta-23-ene-3,25-diol. betulin showed anti-hsv-1 activity with ec50 value of 84.37±0.02 µg/ml, and toxicity on normal vero cells with cc50 value of 660.718±0.072 µg/ml. (3β,23e)-cycloarta-23-ene-3,25-diol showed antiviral effect with ec50 value of 86.63±0.03 µg/ml, and toxicity with cc50 value of 1089.21±0.25 µg/ml. the results revealed that these two compounds have the antiviral activity far below the cc50 value with selectivity index (cc50/ec50) values of 7.83, and 12.57, respectively.
منابع مشابه
Triterpenes and steroids from Euphorbia denticulate Lam. with Anti-Herpes Symplex virus activity
In this research, dried acetone:chloroform extract of aerial parts of E. denticulata as one of the endemic plants to Iran, afforded a number of triterpenes and steroids including: betulin, 24-methylene-cycloart-3-ol, cycloart-23Z-ene-3β,25-diol, cycloart-23Z-ene-3β,25-diol, ergosta-8,24-dien-3-ol (obtusifoliol) and beta-sitosterol which were reported for the first time from this plant. The stru...
متن کاملTriterpenes and steroids from Euphorbia denticulate Lam. with Anti-Herpes Symplex virus activity
In this research, dried acetone:chloroform extract of aerial parts of E. denticulata as one of the endemic plants to Iran, afforded a number of triterpenes and steroids including: betulin, 24-methylene-cycloart-3-ol, cycloart-23Z-ene-3β,25-diol, cycloart-23Z-ene-3β,25-diol, ergosta-8,24-dien-3-ol (obtusifoliol) and beta-sitosterol which were reported for the first time from this plant. The stru...
متن کاملTriterpenes and Steroids from Euphorbia denticulata Lam. With Anti-Herpes Symplex Virus Activity
In this research, dried acetone:chloroform extract of aerial parts of E. denticulata as one of the endemic plants to Iran, afforded a number of triterpenes and steroids including: betulin, 24-methylene-cycloart-3-ol, cycloart-23Z-ene-3β,25-diol, cycloart-23E-ene-3β,25- diol, ergosta-8,24-dien-3-ol (obtusifoliol) and beta-sitosterol which were reported for the first time from this plant. The str...
متن کاملTriterpenes from Euphorbia spinidens with immunomodulatory activity
Dried aceton-chloroform extract of aerial parts of Euphorbia spinidens Bornm. ex Prokh. endemic to Iran, yielded two new triterpenoids, lup-20(29)-ene-33, 28 diol commonly known as betulin and (3β,23E)-Cycloarta-23-ene-3,25-diol. The structures of the isolated compounds were elucidated by 13C- and 1H-NMR as well as 2D-NMR, IR and by the aid of mass fragmentation pattern. In phagocyte chemilumin...
متن کاملtriterpenes from euphorbia spinidens with immunomodulatory activity
dried aceton-chloroform extract of aerial parts of euphorbia spinidens bornm. ex prokh. endemic to iran, yielded two new triterpenoids, lup-20(29)-ene-33, 28 diol commonly known as betulin and (3β,23e)-cycloarta-23-ene-3,25-diol. the structures of the isolated compounds were elucidated by 13 c- and 1 h-nmr as well as 2d-nmr, ir and by the aid of mass fragmentation pattern. in phagocyte chemilum...
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عنوان ژورنال:
iranian journal of pharmaceutical researchجلد ۱۲، شماره ۴، صفحات ۷۵۹-۷۶۷
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